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A New Affinity Tag for Protein Purification

Researchers at Pohang University of Science & Technology have developed a novel technique to affinity tag and purify recombinant proteins.  Their method does not rely on protein-based affinity ligands, but rather utilizes cucurbiturils, a family of macrocyclic molecules named after their resemblance to pumpkins (family Cucurbitaceae).

Coronavirus vaccines moving forward

Development of COVID-19 vaccines is moving forward at an unprecedented pace, and the public interest and press coverage are huge. And yet it is not easy for lay person or scientist to keep track of the multitude of vaccine candidates.

Break-through in mitochondrial gene editing

Mitochondria, the organelles that produce most of a cell’s energy, are distinguished from other organelles by having their own genetic information which is independent of the nucleus. The mitochondrial genome encodes for only 13 proteins, but these proteins are not only very important for energy generation; mutations in these genes are known to be responsible for a number of inherited diseases and they have been implicated in metabolic diseases, aging and neurodegeneration.

Chemotherapy leads to drug resistance in tumor blood vessels

Scientists at Hokkaido University have published research on the effects of chemotherapy on the cells that line the blood vessels inside tumors. They found that, in response to first-line chemotherapy, these tumor endothelial cells (TEC) can become drug-resistant, which allows the tumors themselves to survive chemotherapy and metastasize.

Super-antibodies against SARS-CoV-2 show promising results in animals

If you’ve been following biomedical news on the novel coronavirus over the last several months, there’s a good chance you’ve heard about the potential for antibodies from recovered COVID-19 patients (convalescent antibodies) to help fight the virus and provide temporary immunity to healthcare workers and other persons at high risk of contracting the virus.