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mAbs: The Rory Story

My family’s dog, Rory, has always been weird. He will start screaming if, while running around the house like a maniac, he accidentally stubs his toe. He loves eating carrots. He gets jealous if two people are hugging and he isn’t included. He will only lie down on the softest pillow on the couch. He likes to sit on our laps after we’ve eaten dinner and flops over with wild abandon, confident that someone will catch him before he falls. He has been known to collect items such as books, shoes, and pencils in a particular corner of the living room. He is exceptionally food motivated and sometimes obnoxious in his relentless pursuit of affection.

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A New Affinity Tag for Protein Purification

Researchers at Pohang University of Science & Technology have developed a novel technique to affinity tag and purify recombinant proteins.  Their method does not rely on protein-based affinity ligands, but rather utilizes cucurbiturils, a family of macrocyclic molecules named after their resemblance to pumpkins (family Cucurbitaceae).

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Break-through in mitochondrial gene editing

Mitochondria, the organelles that produce most of a cell’s energy, are distinguished from other organelles by having their own genetic information which is independent of the nucleus. The mitochondrial genome encodes for only 13 proteins, but these proteins are not only very important for energy generation; mutations in these genes are known to be responsible for a number of inherited diseases and they have been implicated in metabolic diseases, aging and neurodegeneration.

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Chemotherapy leads to drug resistance in tumor blood vessels

Scientists at Hokkaido University have published research on the effects of chemotherapy on the cells that line the blood vessels inside tumors. They found that, in response to first-line chemotherapy, these tumor endothelial cells (TEC) can become drug-resistant, which allows the tumors themselves to survive chemotherapy and metastasize.

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