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Break-through in mitochondrial gene editing

Mitochondria, the organelles that produce most of a cell’s energy, are distinguished from other organelles by having their own genetic information which is independent of the nucleus. The mitochondrial genome encodes for only 13 proteins, but these proteins are not only very important for energy generation; mutations in these genes are known to be responsible for a number of inherited diseases and they have been implicated in metabolic diseases, aging and neurodegeneration.

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Chemotherapy leads to drug resistance in tumor blood vessels

Scientists at Hokkaido University have published research on the effects of chemotherapy on the cells that line the blood vessels inside tumors. They found that, in response to first-line chemotherapy, these tumor endothelial cells (TEC) can become drug-resistant, which allows the tumors themselves to survive chemotherapy and metastasize.

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CRISPRing out Host Cell Proteins

In a recent Nature Communications paper titled "Multiplex secretive engineering enhances recombinant protein production and purity", scientists from the Technical University of Denmark and the University of California, San Diego, describe their work to create a...

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Clinical trials in the time of COVID-19

FDA has issued guidelines  for the conduct of clinical trials during the COVID-19 pandemic. “With this guidance issued today, the FDA is helping industry and investigators navigate the COVID-19 pandemic and help assess how to move forward with critical clinical...

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