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Biologics

G is for Gene Therapy

Gene therapy aims to fix a faulty gene or replace it with a healthy gene to try to cure disease or make the body better able to fight disease. It holds promise as a treatment for a wide range of diseases, including cancer, heart disease, diabetes, and inherited...

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First T-cell Engager Has Been Approved

As widely reported, earlier this week FDA approved the first in a novel class of immuno-oncology drugs called bispecific T-cell engagers for the treatment of small cell carcinoma. Small cell carcinoma, an aggressive type of lung cancer, currently has a few effective...

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F is for Filtration

Bioprocess filtration comprises the use of filtration techniques to purify and separate biological substances during the production of all biologics, proteins, nucleic acids, and viruses. Filtration plays a critical role in ensuring the safety, efficacy, and quality...

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E is for Eggs

Chicken egg yolk antibodies, immunoglobulin Y, abbreviated IgY, are a type of antibody found in birds and reptiles, but not mammals. Like other immunoglobulins, IgY are a critical part of organisms’ immune response to foreign substances including pathogens. IgY are...

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Monoclonals for Severe Asthma

Severe asthma affects between nine and 15 million people worldwide, causing chest tightness and difficulty breathing in addition to frequent asthma attacks that sometimes require hospitalization. It is usually treated with inhaled corticosteroids such as fluticasone...

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ADC to Help People with Sickle Cell

Sickle cell disease is a set of genetic conditions where abnormalities in the structure of hemoglobin cause red blood cells to take on a long, curved, sickle-like shape, which can then impede blood flow. Gene therapies may make a huge difference in the lives of...

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Nobel Prize Awarded for mRNA Vaccines against COVID

The 2023 Nobel Prize in Physiology or Medicine was announced today, and has been awarded to Drs. Karolin Karikó and Drew Weissman for their “discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19”....

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D is for DNase

This year marks 30 years since the approval of the biologic dornase alfa, a recombinant DNA degrading enzyme for the treatment of cystic fibrosis. Dornase alfa is a recombinant human deoxyribonuclease I (rhDNase) which selectively cleaves DNA and degrades...

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C is for Checkpoint Inhibitors

Immune checkpoints are a normal part of the immune system. They prevent an immune response from being so strong that it destroys healthy cells. Immune checkpoints engage when proteins on the surface of T cells recognize and bind to partner proteins on other cells,...

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